Last edited by Vilmaran
Wednesday, July 29, 2020 | History

2 edition of impact of CYP2A6 genotype on smoking behaviour and cessation in a nicotine replacement therapy clinical trial. found in the catalog.

impact of CYP2A6 genotype on smoking behaviour and cessation in a nicotine replacement therapy clinical trial.

Viba Malaiyandi

impact of CYP2A6 genotype on smoking behaviour and cessation in a nicotine replacement therapy clinical trial.

by Viba Malaiyandi

  • 10 Want to read
  • 6 Currently reading

Published .
Written in English


About the Edition

We investigated the effect of slow metabolism, predicted by CYP2A6 genotypes resulting in ≤50% activity, on smoking behaviour and treatment outcome with the nicotine patch and spray. CYP2A6 slow versus normal metabolizers had lower metabolic activity, indicated by the 3-hydroxycotinine/cotinine ratio, and smoked fewer cigarettes/day. With the nicotine patch, slow metabolizers maintained greater nicotine levels and percent nicotine replacement compared to normal metabolizers while using equal numbers of patches/week. With the nicotine spray slow metabolizers achieved similar nicotine levels and percent nicotine replacement to normal metabolizers by using fewer sprays/day. A low 3-hydroxycotinine/cotinine metabolite ratio (low CYP2A6 activity) predicted greater abstinence on the patch compared to high CYP2A6 activity but not on the spray. Thus, slow metabolism predicted greater nicotine levels, and cessation on the nicotine patch, while with the spray (dose titration) nicotine levels and cessation were similar between the groups. Thus, rates of nicotine metabolism influence, in part, smoking behaviour and cessation with nicotine replacement therapy.

The Physical Object
Pagination152 leaves.
Number of Pages152
ID Numbers
Open LibraryOL19217615M
ISBN 100494074590


Share this book
You might also like
Novel high-gain, improved-bandwidth, finned-ladder V-band traveling-wave tube slow-wave circuit design

Novel high-gain, improved-bandwidth, finned-ladder V-band traveling-wave tube slow-wave circuit design

Myths of Greece and Rome

Myths of Greece and Rome

economics and politics of the socialist debacle

economics and politics of the socialist debacle

Bridging the divide

Bridging the divide

Sexual health

Sexual health

Reaching people from the pulpit

Reaching people from the pulpit

Goodnight, Bo Bear

Goodnight, Bo Bear

Theory of modelling and simulation

Theory of modelling and simulation

The Queens jewellery

The Queens jewellery

In-service training needs of nutrition field workers and community nutrition technicians in Kiambu District in Kenya

In-service training needs of nutrition field workers and community nutrition technicians in Kiambu District in Kenya

Impact of CYP2A6 genotype on smoking behaviour and cessation in a nicotine replacement therapy clinical trial by Viba Malaiyandi Download PDF EPUB FB2